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Key Papers

  1. Jason G. Andrade, M.D., Heart Rhythm PV signal interpretation during Cryoablation for atrial fibrillation, Heart Rhythm, Volume 12, Issue 6, 1387 – 1394.
  2. Jason G. Andrade, M.D., et al. The Biophysics and Biomechanics of Cryoballoon Ablation, PACE 2012; 35:1162–1168.
  3. Arash Aryana, MS et al. Procedural and biophysical indicators of durable pulmonary vein isolation during cryoballoon ablation of atrial fibrillation, Heart Rhythm 2016;13:424–432.
  4. Shaojie Chen, Schmidt B, Bordignon S, et al. Atrial fibrillation ablation using cryoballoon technology: Recent advances and practical techniques. J Cardiovasc Electrophysiol, 2018;29:932–943.
  5. Karl-Heinz Kuck, et al., Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation (FIRE & ICE Trial) N Engl J Med, 2016. 374(23): p. 2235-45.
  6. Wilber Su, et al., Best practice guide for cryoballoon ablation in atrial fibrillation: The compilation experience of more than 3000 procedures, Heart Rhythm 2015 Volume 12, Issue 7, 1658 – 1666.
  7. Wilber Su, et al., Cryoballoon Best Practices II: Practical guide to procedural monitoring and dosing during atrial fibrillation ablation from the perspective of experienced users, Heart Rhythm 2018, Volume 15, Issue 9, 1348 – 1355.
  8. Mitsuru Takami, et al., Techniques for reducing air bubble intrusion into the left atrium during radiofrequency catheter and cryoballoon ablation procedures: An ex vivo study with a high-resolution camera, Heart Rhythm, Volume 16, Issue 1, 128 – 139.

Additional Reading

  1. Arash Aryana, MS et al. Verification of a novel atrial fibrillation cryoablation dosing algorithm guided by time-to-pulmonary vein isolation: Results from the Cryo-DOSING Study (Cryoballoon-ablation DOSING Based on the Assessment of Time-to-Effect and Pulmonary Vein Isolation Guidance), Heart Rhythm, 2017 Volume 14, Issue 9, 1319 – 1325.
  2. Serge Boveda, et al., Cryoballoon ablation in early persistent atrial fibrillation patients: single procedure outcomes following pulmonary vein isolation in the prospective multicenter CRYO4PERSISTENT AF Study, EP Europace, Volume 20, Issue suppl_1, March 2018, Page i123.
  3. Chao-feng Chen, et al. Comparison of catheter ablation for paroxysmal atrial fibrillation between cryoballoon and radiofrequency: a meta-analysis. Journal of Interventional Cardiac Electrophysiology 48.3 (2017): 351-366.
  4. Ciconte, Giuseppe, et al. Towards a tailored cryo-pulmonary vein isolation. Lessons learned from second-generation cryoballoon ablation. Trends in cardiovascular medicine, 2018.
  5. Kyoung Ryul Julian Chun, Schmidt B, Metzner A, et al. The ‘single big cryoballoon’ technique for acute pulmonary vein isolation in patients with paroxysmal atrial fibrillation: a prospective observational single centre study. Eur Heart J. 2009;30(6):699–709.
  6. Justin Ghosh, Mark A McGuire, Atrial flow dynamics as a determinant of tissue temperature during balloon cryoablation, EP Europace, Volume 20, Issue FI_3, November 2018, Pages f451–f457.
  7. Shoei K. Stephen Huang and John Miller, Catheter Ablation of Cardiac Arrhythmias E-book. Elsevier Health Sciences, 2019.
  8. Atul Verma, et al., Approaches to Catheter Ablation for Persistent Atrial Fibrillation. New England Journal of Medicine (START AF II Trial), 2015. 372(19): p. 1812-1822, N Engl J Med 2015; 372:1812-1822.
  9. Yong Zheng, et al, Comparison of ablation efficacy with cryoballoon or radiofrequency for the treatment of atrial fibrillation: a meta-analysis of randomized controlled trials, Int J Clin Exp Med 2017;10(10):14309-14320.


Terms & Conditions

Products shown for informational purposes only – not meant as a promotion or offer for sale – certain components are pending CE Mark, not available for sale in the European Economic Area (EEA).

CAUTION: The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings and instructions for use can be found in the product labelling supplied with each device. Information for use only in countries with applicable health authority registrations. Material not intended for use in France.

2019 Copyright © Boston Scientific Corporation. All rights reserved

Results from case studies are not necessarily predictive of results in other cases. Results in other cases may vary.

IMPORTANT INFORMATION: These materials are intended to describe common clinical considerations and procedural steps for the use of referenced technologies but may not be appropriate for every patient or case. Decisions surrounding patient care depend on the physician’s professional judgment in consideration of all available information for the individual case.

Boston Scientific (BSC) does not promote or encourage the use of its devices outside their approved labelling.  Case studies are not necessarily representative of clinical outcomes in all cases as individual results may vary.

EP-622001-AA MAR2019